I do think that could be very interesting.

However, if you are doing this, please be careful. Make sure you research side effects, interactions with drugs, foods, other supplements, etc, how they might affect or aggravate any medical conditions you have.

Valerian is considered a folk remedy for heart problems and can cause heart palpitations. It's also a sedative, so you shouldn't take it with alcohol or other sedatives, and you probably should avoid driving or anything like that (but since you're taking it before bed it should be alright.) Also, because of the effect on the heart, you shouldn't take nasal decongestants or other medicines that contain substances that also affect the heart.

I also just read that it can be physically addictive, so you should keep track of how much you are taking. But since you take it very rarely you should be OK.

I also didn't know anything about Calea Zachatachichi so I did a quick google search and there don't seem to be any negative side effects reported. However, like any other foreign substance, in the long run it probably puts a bit of a strain on the kidneys and liver to excrete it from your body, so use in moderation

Good luck.